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Pregnancy, breastfeeding, and certain medications (sulfonylureas, insulin) require dose adjustment or alternative approaches

[82] Potential benefits of azithromycin therapy is azithromycin's good safety profile, minimal treatment burden, and cost-effectiveness, but the drawbacks are gastrointestinal side effects with weekly dosing, which are ameliorated by a split dose regimen

3 GLP-1 signaling reaches the brain through both direct hormone signaling and broader gut-brain communication pathways involved in appetite regulation

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