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Common patch ingredients (berberine, green tea extract, cinnamon) have modest metabolic evidence when taken orally at high doses, but zero published pharmacokinetic data shows they absorb through the skin from an adhesive patch at therapeutic levels

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A 2025 Nature Communications study (Mastaitis et al

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Those with multiple baseline risk factors, such as age greater than 60 and on chronic methylprednisolone, are at even higher risk of these serious side effects if a quinolone antibiotic is also prescribed