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Traditional peptides like insulin or GLP-1 agonists have near-zero oral bioavailabilityproteases in the stomach and small intestine cleave peptide bonds within minutes, and what little survives is metabolised by cytochrome P450 enzymes in the liver before reaching systemic circulation

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As the techniques become more integrated and sophisticated, one could consider approaches such as near-infrared light technology alone or combined with optogenetics [366]

In today's world, it has become necessary to view this issue from a broader perspective, analyse indicators in multiple ways, and develop new strategies