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In many bacteria, the reactions of the -oxidation cycle can be carried out by multiple proteins (FadA to FadM), with FadE as the acyl-CoA dehydrogenase, FadB as the dual enoyl-CoA hydratase and 3-hydroxylacyl-CoA dehydrogenase, and FadA as the 3-ketoacyl-CoA thiolase (see Fig 1

Building on the search conducted for the 2022 pharmacotherapy revision, we conducted a systematic literature review (search dates January 2022 to July 2024), supplemented by relevant trials published through May 2025, to identify studies assessing the efficacy of pharmacotherapy for weight management