The MHRA advises checking B12 levels in patients taking metformin who develop symptoms of deficiency or have risk factors, with periodic monitoring in at-risk patients
According to the 2025 meta-analysis by Alfalasi and colleagues, sublingual B12 showed an approximate 199% mean increase in serum B12 compared to approximately 307% for intramuscular injections
An incorrectly administered intramuscular injection can lead to severe pain, nerve damage, and long-term health complications
Each vitamin plays a unique and irreplaceable role in the body: Vitamin B6 : This vitamin is essential for protein metabolism, the production of neurotransmitters such as serotonin and dopamine, and the synthesis of hemoglobin , which is crucial for oxygen transport in the blood
For individuals with atrophic gastritis, pernicious anaemia, or those taking proton pump inhibitors , food-bound B12 absorption is already compromised