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Fuchs, W., Klupp, B

Factors like inflammation, oxidative stress, and nutritional deficiencies accelerate telomere shortening, contributing to diseases such as cardiovascular issues, dementia, stroke, and cancers

In animal studies, transgenic mice expressing A1AT have shown increased transcription and secretion of IL-1 receptor agonist (IL-1Ra) which has anti-inflammatory effects

Mitochondrial DNA (mtDNA) depletion and mutations in certain mitochondrial genes are linked to reduced insulin secretion and increased oxidative stress, although studies on the exact mechanisms are scarce (Lev et al., 2006)