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Accumulating evidence further demonstrates that in pSS models, reduced gut microbiome diversity and diminished production of microbiota-derived metabolites lead to decreased tolerogenic dendritic cells (DCs) and Th17/Treg imbalance, consequently promoting autoantibody accumulation and exacerbation of glandular inflammatory responses in pSS (203)

Levothyroxine can lower the levels of steroid hormones in your body, so it can worsen adrenal insufficiency and could potentially trigger an adrenal crisis

Unlike PTH, PTHRrP analogs such as Abalo has been shown to bind more selectively to the RG conformation of PTHR1 and thus induces more transient signaling responses

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- Protects the brain and nervous system