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Its primary function is to disrupt the interaction between FOXO4 and the tumor suppressor protein p53, leading to the selective apoptosis of senescent cells and a deceleration of biological aging

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Michaelson JJ

We have solved the structures of the pi class GST hP1-1 in complex with its substrate, glutathione, a transition-state complex, the Meisenheimer complex, and an inhibitor, S-(rho-bromobenzyl)-glutathione, and refined them to resolutions of 1.8 A, 2.0 A and 1.9 A, respectively