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Husain M, Birkenfeld AL, Donsmark M, PIONEER 6 Investigators, et al

The disruption may temporarily affect how nerves communicate, leading to changes in feeling

In this form of polyneuropathy, the first nerve fibers to malfunction are those most distant from the central nervous system, with symptoms such as pain and numbness felt symmetrically in the feet, and then traveling up the legs as the condition progresses

This shift is driven by the parallel global epidemics of type 2 diabetes mellitus (T2DM) and obesity, which fuel the rise of metabolic dysfunction-associated steatotic liver disease (MASLD) (Danpanichkul et al., 2025

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