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Similarly, MTT or CCK-8 assays may reflect metabolic activity or cell viability and should not be treated as definitive proof of cell proliferation without supporting cell-cycle, DNA-synthesis, or direct cell-counting data

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Intriguingly, emerging evidence suggests that some newer agents such as ocrelizumab (a B cell-depleting monoclonal antibody) and siponimod (a sphingosine 1-phosphate receptor modulator with anti-inflammatory and neuroprotective properties) are beneficial in progressive MS, potentially with effects independent of suppressing acute inflammation (Montalban et al., 2017