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This dual mechanism, weight-mediated and insulin-mediated aromatase reduction, may explain why some endometriosis patients see improvements that seem disproportionate to their weight loss alone

Aging disrupts this process through cell cycle arrest mediated by p53 and p21, which halt hepatocyte proliferation, particularly in chronic injury or disease

R., Kirsop, J., Wang, Z., Levison, B

Cell Death Dis 10 , 321 (2019)

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