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The primary cause of glucotoxicity is insulin resistance, which arises from defective islet cell function and damage caused by reduced insulin mRNA expression, associated with diminished transcription or activity of transcription factors involved in insulin production (Danil and Michala, 2011)

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Unfortunately, during the same period, the incidence of primary biliary cancer (ICC) was increasing, especially in the population of people 65 years old (213)