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There is often a concentration gradient within the hepatic lobule with more extensive lobular involvement associated with higher doses of the toxic agent

The carnitine transport system in the liver has been characterized in human, rat and mouse ( Ramsay et al., 2001 )

Mitochondrial Effects of Common Cardiovascular Medications: The Good, the Bad and the Mixed

However, MM is still incurable for the majority of patients who become refractory to treatment and ultimately relapse, thus further development of new therapeutic agents is warranted, such as specific inhibitors targeting activated oncogenes