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Gallbladder-related issues such as cholelithiasis or cholecystitis have also emerged in some cases, particularly among individuals who lose weight rapidly

The pressure helps seal damaged blood vessels and prevents bruising

Table 2 illustrates how the microbiome may be effected by long-term PPI use

That said, tolerability is broadly similar across the three compounds: gastrointestinal adverse events dominate, and slow titration is the universal strategy for managing them