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Although this seems promising, there is very little evidence supporting topiramates effectiveness, and it does have adverse effects in the brain such as paresthesias (abnormal burning or prickling sensation) [23]

10.1210/jcem.80.6.7775643 45 KimuraM.InoueH.HirabayashiK.NatsumeH.OgiharaM

However, when intracellular levels of labile Fe2+ become excessively high, it reacts with hydroxyl radicals via the Fenton reaction, triggering a surge in reactive oxygen species (ROS) production and the accumulation of lipid peroxidation

3 Molecular functions of ChaC1 ChaC1 and its homologues function as -glutamyl cyclotransferases (GCTs) that specifically degrade glutathione

However, no large-scale human clinical trials have been completed, so long-term safety data in humans remains limited