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Given that glutathione is the most abundant thiol in the mitochondria 36, 37 , it is no surprise that ETHE1 exhibits high specificity for glutathione persulfide as its substrate

Sep 2004;1(4):24-29

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Subsecuentemente, la activacin de vas de sealizacin secundarias, incluyendo protena quinasa A (PKA) y Epac2, alteran la actividad de los canales de iones celulares, causando niveles elevados de calcio citoslico que aumentan la exocitosis de grnulos contenedores de insulina