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The Phase 2 COURAGE trial reported that about 35% of semaglutide-induced weight loss was from lean mass ( Regeneron Newsroom )

1.3% with placebo 84% achieved 5% weight reduction (vs

Avoid using semaglutide if you have multiple endocrine neoplasia type 2 (tumors in your glands) or if you or your family have a history of medullary thyroid cancer

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Outside MAP: If a patient does not meet the protocol criteria, liraglutide 3mg may still be prescribed, but only on a private basis, meaning that the full cost of treatment is borne by the patient