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Table 1 presents the demographic and clinical characteristics of the reported cases, stratified by gender distribution, age groups, body weight categories, reporter profiles, geographical origin, and clinical outcomes
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One compelling histopathological correlate of disability progression is the slowly-expanding lesion, characterized by a presumably inactive gliotic demyelinated center surrounded by a rim of activated microglia and macrophages containing degenerated myelin, injured axons and often iron deposition (Dal-Bianco et al., 2017