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Overall, these studies demonstrate that lipolysis is regulated by intermediary metabolites of FAs and that ABHD5 is an intracellular receptor and transducer of metabolic signals (Figure 1)

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This phase 2 study compared brodalumab against placebo in patients with active PsA (both non-exposed and exposed to prior biologic therapy) to a primary endpoint of 20% improvement of American College of Rheumatology (ACR) criteria at week 12