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Metformin is contraindicated when eGFR falls below 30 mL/min/1.73 m2 and dose reduction is recommended when eGFR is 30 to 45 mL/min/1.73 m2, per the FDA Drug Safety Communication (2016)

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During clinical trials, Wegovy demonstrated an average weight loss of 15% over 68 weeks

They help trigger insulin, slow down how fast your stomach empties, and tell your brain youve had enough to eat

This is one reason they need to be taken daily instead of weekly like injections