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Written by: Chris Butt, Certified Personal Trainer & Weight Loss Coach, Premier Fitness Camp | Last updated: July 13, 2026 Most people notice strength gains within 48 weeks of consistent resistance training after GLP-1 use

Frailty is characterized by biomarker patterns reflecting inflammation or muscle catabolism in multi-morbid patients

Some patients plateau earlier

The most common week one side effects are: Nausea, especially in the first 24 to 48 hours after injection Reduced appetite, sometimes to the point of not wanting to eat at all Fatigue and low energy Loose stools or constipation Mild headache Dizziness when standing up quickly These are not signs something is wrong

Smile: Acknowledging the positive impact of a smiling disposition