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There is no official contraindication or direct drug interaction between caffeine and semaglutide (marketed as Ozempic, Wegovy, and Rybelsus) listed in the FDA prescribing information

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No one should exceed the recommended limits, and it must be taken under professional supervision

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The most common side effect with this new medication like many medications is mild nausea, and it is not a stimulant, so those patients that have not been able to tolerate Phentermine or similar medications can take a GLP-1 medication alone to help with their appetite