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Moreover, cancer cells carrying mutations of succinate dehydrogenase, fumarate hydrolase or isocitrate dehydrogenase accumulate -KG competitors including succinate, fumarate and 2-hydroxyglutarate, respectively 43,49,50

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Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H

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mTOR regulates the proliferation and activation of B lymphocytes B cells participate in the pathogenesis of RA by producing autoantibodies, proinflammatory cytokines, and chemokines, acting as efficient antigen-presenting cells and regulating T cell activation and differentiation [69, 70]