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This indicates that GSH is the main reductant responsible for maintaining the ER oxidoreductases in a reduced form, which is necessary for the reduction or isomerization of nonnative disulphide bonds

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At the level of thyroid hormone synthesis, TNF- can directly inhibit the activity of thyroid peroxidase (TPO), and IL-1 stimulates iodothyronine 5-deiodine activity in the liver to affect the metabolism of thyroid hormone (Fujii et al., 1989)

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However, there was no documented evidence of increased survival in the finasteride group