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Studies have suggested that excess Mn can compromise BBB integrity by increasing leakiness and reducing tight junction proteins (Oliveira-Paula et al., 2024

Unfortunately, viral gene therapy presents the risk of insertional mutagenesis and does not reliably yield high expression profiles (Monahan and Samulski, 2000)

Journal reference: Diab H, Fuquay T, Datta P, Bickel U, Thompson J, Krutsch K

Some procedures, like IPL or a light micropeel, may be done on the same day as injection, as long as it is done before injection

We have been careful not to make our meta-analyses a prominent component of the review, but rather to use the data to identify the extent of confounding and selection biases and to examine possible sources of heterogeneity between the results of individual observational studies