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After 28 days, oxidation reduces potency below clinically effective levels a stability study published in the International Journal of Pharmaceutics found potency dropped to 78% at day 35 and 61% by day 42

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A smaller placebo-controlled trial showed that oral administration of 300 mg/day of coenzyme Q 10 for 48 to 96 months moderately improved motor symptoms in treated patients (with Levodopa) with re-emerging symptoms but not in patients at an early stage of the disease (67)