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Today, Vitamin B12 deficiency is all too common and creates acute and chronic illnesses, as well as a variety of unpleasant symptoms

Ethics statement The animal study was approved by The Ethics Committee approved all procedures for Animal Research of King Saud University, Riyadh (IRB No: KSU-SE-23-58)

In its strict sense, chronobiotics refer to agents capable of entraining or phase-shifting circadian rhythms through direct action on the central or peripheral clocks, with melatonin representing the prototypical example (Zawilska et al., 2009)

That systematic review is a clinical-evidence review, and it concluded that human clinical evidence for BPC-157 is lacking