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The evidence is unambiguous: refrigeration between 28C is the only validated storage condition for maintaining potency across the 2890 day use window

56 Small molecule targeted therapy (BRAF and MEK inhibitors) and immune checkpoint inhibitors (CTLA4 and PD1) have shown promising clinical outcomes

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The deleterious mechanisms activated during the ischemia and reperfusion phases in MI include oxygen deprival, decreased availability of nutrients and survival factors, accumulation of waste products, generation of oxygen free radicals, calcium overload, neutrophil infiltration in the ischemic area, depletion of energy stores, and opening of the mitochondrial permeability transition pore, all of them contributing to the activation of apoptosis and necrosis in cardiomyocytes