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Lipoxygenases enzymatically oxidize PUFAs, leading to lethal lipid peroxidation and cell death ( ) is essential for glutathione synthesis, and its dysfunction exacerbates ferroptosis by impairing cystine uptake ( ROS are central to ferroptosis, as they drive lipid peroxidation

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Another study showed that oral daily glutathione supplementation over 4 months combined with improvements in lifestyle habits led to positive effects on the liver for some people with non-alcoholic fatty liver disease (11)