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In SURPASS-2, severe hypoglycemia (requiring third-party assistance) occurred in fewer than 0.6% of tirzepatide-treated participants not on sulfonylureas or insulin, mechanistically expected given the glucose-dependent clamp

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For patients who continued treatment for two years, the STEP 5 trial found average weight loss reached 15.2% , with 77.1% of participants maintaining at least 5% weight reduction

The role of peroxisome proliferator-activated receptors (PPAR) in immune responses