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10.1016/j.ccr.2006.08.009 Cancer Cell 127 van den DobbelsteenD

As concomitant abuse of different drugs is common in todays society, the effects of GLP-1R agonists on the intake on multiple addictive drugs in a situation where the rats can choose between different drugs should be tested

Adult animals were treated with 25 mmol L 1 FA and/or 10 mmol L 1 NAC for 5 h, in the presence of heat-inactivated RNAi-expressing bacteria

Old age is a factor causing significant changes in pharmacokinetics, mainly at the stage of distribution (increased content of adipose tissue and 1 acid glycoprotein, reduced water content and albumin concentration) and elimination (impaired renal function, slower hepatic metabolism) [153, 366]

The top-tier scientific journal, Nature, published the study