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Through ACSL4 induction and provision of oxidizable PUFA substrates, M1 TAMs directly enhance the lipid-peroxidation machinery necessary for ferroptosis execution

Recent experiments confirm that most of the common terminal events in AMD, RP, glaucoma, and DR are RPE or RGC ferroptosis, and single-cell sequencing confirms that ferroptosis signals appear earlier than apoptosis

B12-rich foods like meat, fish, and dairy might be consumed in smaller quantities due to reduced appetite

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The availability of trace minerals can also decline at certain times of the year, such as when cattle are grazing lush, rapidly-growing pastures