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M., Peitta, G., Simile, M

RS brain does not display obvious manifestations of structural neuronal or glial damage [370, 371]

10.1128/IAI.01481-08 8 CruzN

Although this condition may improve once the medication is discontinued, it may still leave some lasting effects

In addition, GPX4 inhibitors remain challenging to use in vivo owing to their poor bioavailability, and pharmacological inhibition of GPX4 carries a substantial risk of systemic toxicity, as demonstrated in GPX4 knockout mouse models 25,26,27 Thus, modulating the CoQ 10 redox cycle, either by inhibiting ubiquinol (CoQ 10 H 2 , reduced) formation or altering oxidoreductase activity, has emerged as an alternative therapeutic strategy for ferroptosis-based cancer therapy