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Here is the problem

First described back in the 1950s, acne erupts in about one in ten people within days or even hours of getting an injection of vitamin B12, which then disappears rapidly when injection treatment is discontinued. At the time, we had no idea what the mechanism might be, and the problem remained unsolved until just a few years ago when we finally figured it out: Vitamin B12 modulates the gene expression of the skin bacteria that cause acne

Muhammad FS, Rehman M, Sarwar HS, Naveed S, Salman O, Bukhari NI, Hussain I, Webster TJ, Shahnaz G

doi: 10.3168/jds.2016-11966 204

Treatment Schedule : If the deficiency is severe, you'll typically need weekly injections initially, for about 46 weeks , until your B12 levels stabilize