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However, clinicians should remain vigilant for signs of excessive metabolic suppression or thyroid dysfunction, particularly in patients with pre-existing thyroid conditions or those experiencing symptoms beyond cold intolerance, such as severe fatigue, hair loss, or cognitive changes that might suggest thyroid hormone imbalance requiring investigation

Regardless of whether this very optimistic statement is true, what is true is that these drugs are effective for most patients who are obese in causing significant BMI reductions that previously would only be achievable with gastric bypass or sleeve gastrectomy

Another factor involves metabolic differences between individuals

The American Thyroid Association guideline on levothyroxine dosing already recommends separating levothyroxine from other drugs and food by 30 to 60 minutes [8]

Brand-name options available: Wegovy and Zepbound for patients who want FDA-approved versions