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doi: 10.1210/en.2010-0745

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Metformin is the guideline-recommended first-line oral agent for type 2 diabetes and is also the step-therapy prerequisite before brand SGLT2 inhibitors and DPP-4 inhibitors on most Blue commercial plans

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We can see very clearly that this is specific to medications that are working through GLP-1 receptor pharmacology, Gloyn said