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Excessive FAs in the circulatory system promote insulin secretion from pancreatic beta cells, upregulate the expression of renal uric acid reabsorption proteins Glucose transporter type 9 (GLUT9) and urate transporter 1 (URAT1), and reduce the level of uric acid excretion protein ATP-binding cassette transporter G2 (ABCG2), resulting in elevated serum uric acid levels ( Figure 4 )

Glutathione transferase alpha as a marker for tubular damage after trichloroethylene exposure

-Cell fate in human insulin resistance and type 2 diabetes: a perspective on islet plasticity

Studies have shown that low-dose aspirin can inhibit the increase of TMAO in the body, along with reducing the platelet overreaction caused by increased TMAO (79)

Beyond its antioxidant duties, this molecule is a central player in the body's natural detoxification pathways