[6] [7] For patients with neurological symptoms, hydroxocobalamin 1mg IM is given on alternate days until no further improvement, followed by maintenance injections of 1mg every two to three months
In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
[DOI] [PMC free article] [PubMed] [Google Scholar] Rajan 2002 Rajan S, Wallace JI, Beresford SA, Brodkin KI, Allen RA, Stabler SP
The good news: All forms of B12 supplements are relatively safe and can help you sidestep symptoms of a deficiency
Fatigue appears in 8-12% of users, though distinguishing medication-induced fatigue from diet-related energy deficits proves difficult