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Further research indicates that combinations of specific compounds, such as icaritin and curcumol, can inhibit PCa progression by modulating the gut microbiota-enriching beneficial taxa, which in turn suppresses DNA methyltransferase 1 expression and activates CD8+ T cell-mediated antitumor immunity (123)

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Common short-term side effects include gastrointestinal discomfort that typically improves with dose titration, while longer-term safety monitoring focuses on metabolic markers, gallbladder disease signals, and rare adverse events identified in post-marketing surveillance

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Hoffmann-La Roche AG, Teva Pharmaceutical Industries Ltd, Viking Therapeutics, Shanghai Benemae Pharmaceutical Corporation, and Biocon Limited are some of the leading players operating in the market