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In eukaryotic organisms, they are actively excreted or compartmentalized in the vacuole by ATP-dependent GS-X pumps [42], [27]

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Suppression of food and water intake by GLP-1 mainly involves interactions with various hypothalamic nuclei, particularly the arcuate and paraventricular nucleus, as well as some hindbrain structures such as the parabrachial nucleus [31]

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