Lymphatic targeting may be achieved via the delivery of macromolecular therapeutics (for example, proteins and peptides), small-molecule therapeutics in association with macromolecular carriers (for example, nanoparticles, polymers, liposomes and dendrimers) or small-molecule therapeutics that associate, in situ , with endogenous macromolecular constructs (for example, lipoproteins and proteins) or cells that are transported from interstitial tissues via lymphatic rather than blood capillaries
It should be stressed that the beneficial results of the use of statins were equally important to the subjects without metabolic syndrome, compared to the ones with metabolic syndrome, proving that the use of statins may have a crucial effect on the management of patients with a genetic disposition to present with NAFLD/NASH, independently of the presence of metabolic syndrome [20]
10.1038/nrgastro.2017.38 150 UemuraA.KusuharaS.WiegandS
DNA Extraction and Genotyping Genomic DNA was extracted from PBMCs of patients using a TIANamp Blood DNA Kit (Tiangen, Beijing, China)
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