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De igual manera, en un metaanlisis realizado por Memon et al.59, en el cual se incluyeron 17 ensayos clnicos y un total de 1009 pacientes, se demostr que el uso concomitante de metformina con probiticos se asocia a menos efectos adversos gastrointestinales (OR=0.18, IC95%=0.09-0.38)