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Over time, these effects may contribute to reduced caloric intake in some patients as part of a medically supervised weight management approach

Women in the ATTAIN-1 study lost up to 30.4 pounds (14.4%) over 72 weeks

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Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use GLP-1 receptor agonists due to thyroid C-cell tumor risk observed in animal studies

Patients who discontinued GLP-1s had more weight gain, complications during pregnancy In a study led by researchers at Mass General Brigham, pregnant individuals who stopped taking popular weight loss GLP-1 medications before or early in their pregnancy tended to gain more weight and have higher risks of diabetes and hypertensive disorders during pregnancy, and experienced preterm delivery more so than people who had never taken GLP-1 drugs