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IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan

(with Kristine Dennis) (2026)

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On the other hand, a vitamin B12 deficiency appears to cause a loss of appetite in some people, leading to weight loss rather than weight gain ( That said, the current evidence is too weak to suggest that a vitamin B12 deficiency has any strong or specific impact on weight be it weight gain or loss

GLP-1 peptide Cagrilintide is a new, long-acting amylin analog that is meant to fix the problems with native amylin by making changes that make the half-life longer and improve metabolic stability