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Efficacy and safety of glucagonlike peptide1 receptor agonists for weight loss among adults without diabetes: a systematic review of randomized controlled trials

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Morton and He (2025) described a small retrospective cohort of 13 women exposed to semaglutide

The primary outcome was the time to primary failure defined as an A1c 7% over an anticipated mean observation period of 5 years The results as expected demonstrated that the GLP-1 receptor agonist liraglutide was more effective than the sulfonylurea glimepiride and the DPP4 inhibitor sitagliptin in maintaining the A1c 180 mg/dl (i.e., secondary failure) (31)