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reported that paricalcitol modulates the Angiopoietin-2/VEGF/VEGFR2 axis, attenuates TGF- related signaling, and preserves renal tissue architecture in an adriamycin nephropathy model (37)

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7 In SURPASS-2, tirzepatide was compared to the GLP-1 RA semaglutide 1 mg which is also considered a treatment with very high efficacy for WL and glycemia improvement in people with T2DM

To assess the potential protective effects of melatonin, cells were pretreated with 25 M melatonin for 20 h before exposing them to 0.8 mM HO for 4 h