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Conversely, an open-label retrospective cohort reported greater reductions in Binge Eating Scale scores among patients receiving semaglutide, and recent reviews have suggested potential benefits of GLP-1RAs for binge-eating behaviour, although large-scale, blinded, placebo-controlled trials remain limited (106, 107)

If your retatrutide seems less effective than it was, if appetite suppression has weakened, or if results have stalled despite consistent dosing, potency loss from improper storage should be one of the first things you investigate

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